Panoramic Images for Situational Awareness in a 3D Chart-of-the-Future Display

Many early charts featured sketches of the coastline, providing a good picture of what the shore looked like from the bridge of a ship. These helped the mariner to distinguish one port from another during an approach and establish their rough position within that approach. More recent experimental 3D chart interfaces have incorporated 3D models of land topography and man-made structures to perform the same function. However, topography is typically captured from the air, by means of stereophotogrammetry or lidar and fails to present a good representation of what is seen from a vessel’s bridge. We have been conducting an investigation of ways to present photographic imagery to the mariner to better capture the utility of the early coastline sketches. Our focus has been on navigation in restricted waters, using the Piscataqua River as a test area. This is part of our “Chart-of-the-Future” project being conducted by The Data Visualization Research Lab at the UNH Center for Coastal and Ocean Mapping. Through our investigation, we have developed a new method for presenting photographic imagery to the mariner, in the form of a series of panoramic images progressing down the channel. The panoramas consist of images stitched almost seamlessly together into circular arcs, whose centers are intended to be close to the position of a vessel’s bridge during transit. When viewed from this center, there is no distortion, and distortion increases to a maximum between two panorama centers. Our preliminary trials suggest that panoramas can provide an excellent supplement to electronic navigation aids by making them visible in the context of what can be seen out the window. We believe panoramas will be especially useful both in familiarizing a mariner with an unfamiliar approach during planning, and in enhancing situational awareness at times of reduced visibility such as in fog, dusk, or nightfall

Fusing Information in a 3D Chart-of-the-Future Display

The Data Visualization Research Lab at the Center for Coastal and Ocean Mapping is investigating how three-dimensional navigational displays can most effectively be constructed. This effort is progressing along multiple paths and is implemented in the GeoNav3D system, a 3D chart-of-the-future research prototype. We present two lines of investigation here. First, we explore how tide, depth, and planning information can be combined (fused) into a single view, in order to give the user a more realistic picture of effective water depths. In the GeoNav3D system, 3D shaded bathymetry, coded for color depth, is used to display navigable areas. As in ENC displays, different colors are used to easily identify areas that are safe, areas where under-keel clearance is minimal, and areas where depths are too shallow. Real-time or model-generated tide information is taken into account in dynamically color-coding the depths. One advantage to using a continuous bathymetric model, versus discrete depth areas, is that the model can be continuously adjusted for water level. This concept is also extended for planning purposes by displaying the color-coded depths along a proposed corridor at the expected time of reaching each point. In our second line of investigation, we explore mechanisms for linking information from multiple 3D views into a coherent whole. In GeoNav3D, it is possible to create a variety of plan and perspective views, and these views can be attached to moving reference frames. This provides not only semi-static views such as from-the-bridge and under-keel along-track profile views, but also more dynamic, interactive views. These views are linked through visual devices that allow the fusion of information from among the views. We present several such devices and show how they highlight relevant details and help to minimize user confusion. Investigation into the utility of various linked views for aiding realsituation decision-making is ongoin

Advanced Mid-Water Tools for 4D Marine Data Fusion and Visualization

Mapping and charting of the seafloor underwent a revolution approximately 20 years ago with the introduction of multibeam sonars -- sonars that provided complete, high-resolution coverage of the seafloor rather than sparse measurements. The initial focus of these sonar systems was the charting of depths in support of safety of navigation and offshore exploration; more recently innovations in processing software have led to approaches to characterize seafloor type and for mapping seafloor habitat in support of fisheries research. In recent years, a new generation of multibeam sonars has been developed that, for the first time, have the ability to map the water column along with the seafloor. This ability will potentially allow multibeam sonars to address a number of critical ocean problems including the direct mapping of fish and marine mammals, the location of mid-water targets and, if water column properties are appropriate, a wide range of physical oceanographic processes. This potential relies on suitable software to make use of all of the new available data. Currently, the users of these sonars have a limited view of the mid-water data in real-time and limited capacity to store it, replay it, or run further analysis. The data also needs to be integrated with other sensor assets such as bathymetry, backscatter, sub-bottom, seafloor characterizations and other assets so that a “complete” picture of the marine environment under analysis can be realized. Software tools developed for this type of data integration should support a wide range of sonars with a unified format for the wide variety of mid-water sonar types. This paper describes the evolution and result of an effort to create a software tool that meets these needs, and details case studies using the new tools in the areas of fisheries research, static target search, wreck surveys and physical oceanographic processes

GeoZui3D: Data Fusion for Interpreting Oceanographic Data

GeoZui3D stands for Geographic Zooming User Interface. It is a new visualization software system designed for interpreting multiple sources of 3D data. The system supports gridded terrain models, triangular meshes, curtain plots, and a number of other display objects. A novel center of workspace interaction method unifies a number of aspects of the interface. It creates a simple viewpoint control method, it helps link multiple views, and is ideal for stereoscopic viewing. GeoZui3D has a number of features to support real-time input. Through a CORBA interface external entities can influence the position and state of objects in the display. Extra windows can be attached to moving objects allowing for their position and data to be monitored. We describe the application of this system for heterogeneous data fusion, for multibeam QC and for ROV/AUV monitoring

Electronic Chart of the Future: The Hampton Roads Project

ECDIS is evolving from a two-dimensional static display of chart-related data to a decision support system capable of providing real-time or forecast information. While there may not be consensus on how this will occur, it is clear that to do this, ENC data and the shipboard display environment must incorporate both depth and time in an intuitively understandable way. Currently, we have the ability to conduct high-density hydrographic surveys capable of producing ENCs with decimeter contour intervals or depth areas. Yet, our existing systems and specifications do not provide for a full utilization of this capability. Ideally, a mariner should be able to benefit from detailed hydrographic data, coupled with both forecast and real-time water levels, and presented in a variety of perspectives. With this information mariners will be able to plan and carry out transits with the benefit of precisely determined and easily perceived underkeel, overhead, and lateral clearances. This paper describes a Hampton Roads Demonstration Project to investigate the challenges and opportunities of developing the “Electronic Chart of the Future.” In particular, a three-phase demonstration project is being planned: 1. Compile test datasets from existing and new hydrographic surveys using advanced data processing and compilation procedures developed at the University of New Hampshire’s Center for Coastal and Ocean Mapping/Joint Hydrographic Center (CCOM/JHC); 2. Investigate innovative approaches being developed at the CCOM/JHC to produce an interactive time- and tide-aware navigation display, and to evaluate such a display on commercial and/or government vessels; 3. Integrate real-time/forecast water depth information and port information services transmitted via an AIS communications broadcast

An interdisciplinary clinical practice model for the management of low-back pain in primary care: the CLIP project

<p>Abstract</p> <p>Background</p> <p>Low-back pain is responsible for significant disability and costs in industrialized countries. Only a minority of subjects suffering from low-back pain will develop persistent disability. However, this minority is responsible for the majority of costs and has the poorest health outcomes. The objective of the Clinic on Low-back pain in Interdisciplinary Practice (CLIP) project was to develop a primary care interdisciplinary practice model for the clinical management of low-back pain and the prevention of persistent disability.</p> <p>Methods</p> <p>Using previously published guidelines, systematic reviews and meta-analyses, a clinical management model for low-back pain was developed by the project team. A structured process facilitating discussions on this model among researchers, stakeholders and clinicians was created. The model was revised following these exchanges, without deviating from the evidence.</p> <p>Results</p> <p>A model consisting of nine elements on clinical management of low-back pain and prevention of persistent disability was developed. The model's two core elements for the prevention of persistent disability are the following: 1) the evaluation of the prognosis at the fourth week of disability, and of key modifiable barriers to return to usual activities if the prognosis is unfavourable; 2) the evaluation of the patient's perceived disability every four weeks, with the evaluation and management of barriers to return to usual activities if perceived disability has not sufficiently improved.</p> <p>Conclusion</p> <p>A primary care interdisciplinary model aimed at improving quality and continuity of care for patients with low-back pain was developed. The effectiveness, efficiency and applicability of the CLIP model in preventing persistent disability in patients suffering from low-back pain should be assessed.</p

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe